RNA Interference in Protozoan Parasites: Achievements and Challenges
نویسندگان
چکیده
منابع مشابه
RNA interference in protozoan parasites: achievements and challenges.
Protozoan parasites that profoundly affect mankind represent an exceptionally diverse group of organisms, including Plasmodium, Toxoplasma, Entamoeba, Giardia, trypanosomes, and Leishmania. Despite the overwhelming impact of these parasites, there remain many aspects to be discovered about mechanisms of pathogenesis and how these organisms survive in the host. Combined with the ever-increasing ...
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Over the past 15 years, DNA vaccines have gone from a scientific curiosity to one of the most dynamic research field and may offer new alternatives for the control of parasitic diseases such as leishmaniasis and Chagas disease. We review here some of the advances and challenges for the development of DNA vaccines against these diseases. Many studies have validated the concept of using DNA vacci...
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When viewed from the top, Trichodina is circular; side views of the organism reveal a saucer or dome shape (Fig. 1). It has three rings of cilia (small, hair-like projections) encircling its body and oral cavity, which are used for locomotion and feeding. Its body is supported by a rigid ring of interconnected discs called a chitinoid or denticular ring (Fig. 2). Each disc has a thorn-like inne...
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Studies on host-pathogen interactions have led to the discovery of various cell surface associated and secretory molecules. Mucins and mucin-like molecules have recently been described in several protozoan parasites, at different stages of the life cycle. These share many structural and compositional features with mammalian mucins, but vary in several other aspects. It is now becoming evident t...
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ژورنال
عنوان ژورنال: Eukaryotic Cell
سال: 2011
ISSN: 1535-9778,1535-9786
DOI: 10.1128/ec.05114-11